Researchers At King’s College London Found That The Drug Tideglusib Stimulates The Stem Cells Contained

End of fillings in sight as scientists find Alzheimer's drug makes teeth grow back
Fillings could be consigned to history after scientists discovered that a drug already trialled in Alzheimer's patients can encourage tooth regrowth and repair cavities.

Researchers at King’s College London found that the drug Tideglusib stimulates the stem cells contained in the pulp of teeth so that they generate new dentine – the mineralised material under the enamel.

Teeth already have the capability of regenerating dentine if the pulp inside the tooth becomes exposed through a trauma or infection, but can only naturally make a very thin layer, and not enough to fill the deep cavities caused by tooth decay.

But Tideglusib switches off an enzyme called GSK-3 which prevents dentine from carrying on forming.

Scientists showed it is possible to soak a small biodegradable sponge with the drug and insert it into a cavity, where it triggers the growth of dentine and repairs the damage within six weeks.

The tiny sponges are made out of collagen so they melt away over time, leaving only the repaired tooth.

More Posts from Ourvioletdeath and Others

7 years ago

Este mes

Siento una soledad frio y terrible sin el calor de tu corazon,

La culpa fue mia, pero me duele sin tu amor

Quisiera haberte dicho esto el 2 de este mes, pero me dolia demasiado escribirlo

Perdi el amor de alguien increible y maravillosa, y honestamente no se que hacer sin ti.

Puedo decir todo esto ahora, porque ya te estas alejando de mi, y aunque lo lamento, yo se que es lo mejor. 

Quiero ser mejor, porque algun dia, en algun futuro, yo espero encontrate y amarte otravez. Y cuando ese dia ocurre, espero que tu tambien quieras lo mismo. 

Te amo con una furia y dolor y no puedo explicar.

Espero que estes contenta, amor, y aunque ya no lo crees por la manera que he estado actuando, te extrano, nada va cambiar eso. 


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7 years ago
6 years ago

😍😍😍😍😍😍

Levi Knocking Kenny Out, S03e02
Levi Knocking Kenny Out, S03e02
Levi Knocking Kenny Out, S03e02
Levi Knocking Kenny Out, S03e02

Levi knocking Kenny out, s03e02

7 years ago
Via @extramadness

via @extramadness

8 years ago
If You Like More Of This, Follow @psych2go​. 

If you like more of this, follow @psych2go​. 

6 years ago

Everyone has the name of their supposed soulmate printed on the inside of your wrist. You, however, are defiant, and begin dating someone that’s not your soulmate. It turns out that not meeting someone with the magic expectation that you’re ‘meant to be for each other and will get married and live happily ever after’ actually made you two get along pretty well, and you’re now deeply in love with them. However, after several years of dating this person, both your and your S.O.’s real ‘soulmates’ find you, and they’re both furious that you didn’t wait for them.

7 years ago
Neurons Have The Right Shape For Deep Learning

Neurons have the right shape for deep learning

Deep learning has brought about machines that can ‘see’ the world more like humans can, and recognize language. And while deep learning was inspired by the human brain, the question remains: Does the brain actually learn this way? The answer has the potential to create more powerful artificial intelligence and unlock the mysteries of human intelligence.

In a study published in eLife, CIFAR Fellow Blake Richards and his colleagues unveiled an algorithm that simulates how deep learning could work in our brains. The network shows that certain mammalian neurons have the shape and electrical properties that are well-suited for deep learning. Furthermore, it represents a more biologically realistic way of how real brains could do deep learning.

Research was conducted by Richards and his graduate student Jordan Guerguiev, at the University of Toronto, Scarborough, in collaboration with Timothy Lillicrap at Google DeepMind. Their algorithm was based on neurons in the neocortex, which is responsible for higher order thought.

“Most of these neurons are shaped like trees, with ‘roots’ deep in the brain and ‘branches’ close to the surface,” says Richards. “What’s interesting is that these roots receive a different set of inputs than the branches that are way up at the top of the tree.”

Using this knowledge of the neurons’ structure, Richards and Guerguiev built a model that similarly received signals in segregated compartments. These sections allowed simulated neurons in different layers to collaborate, achieving deep learning.

“It’s just a set of simulations so it can’t tell us exactly what our brains are doing, but it does suggest enough to warrant further experimental examination if our own brains may use the same sort of algorithms that they use in AI,” Richards says.

This research idea goes back to AI pioneers Geoffrey Hinton, a CIFAR Distinguished Fellow and founder of the Learning in Machines & Brains program, and program Co-Director Yoshua Bengio, and was one of the main motivations for founding the program in the first place. These researchers sought not only to develop artificial intelligence, but also to understand how the human brain learns, says Richards.

In the early 2000s, Richards and Lillicrap took a course with Hinton at the University of Toronto and were convinced deep learning models were capturing “something real” about how human brains work. At the time, there were several challenges to testing that idea. Firstly, it wasn’t clear that deep learning could achieve human-level skill. Secondly, the algorithms violated biological facts proven by neuroscientists.

Now, Richards and a number of researchers are looking to bridge the gap between neuroscience and AI. This paper builds on research from Bengio’s lab on a more biologically plausible way to train neural nets and an algorithm developed by Lillicrap that further relaxes some of the rules for training neural nets. The paper also incorporates research from Matthew Larkam on the structure of neurons in the neocortex. By combining neurological insights with existing algorithms, Richards’ team was able to create a better and more realistic algorithm simulating learning in the brain.

The tree-like neocortex neurons are only one of many types of cells in the brain. Richards says future research should model different brain cells and examine how they could interact together to achieve deep learning. In the long-term, he hopes researchers can overcome major challenges, such as how to learn through experience without receiving feedback.

“What we might see in the next decade or so is a real virtuous cycle of research between neuroscience and AI, where neuroscience discoveries help us to develop new AI and AI can help us interpret and understand our experimental data in neuroscience,” Richards says.

7 years ago

I love the delicate shadow of she wanting me to be

-Conspiracy Theory

One of my most favorite quotes ever, it's beautiful. The movie is pretty great, too.


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ourvioletdeath - Inner Ramblings of the Mind
Inner Ramblings of the Mind

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